Screening for antibodies against the Mi-2α antigen is performed in patients with the potential for polymyositis, dermatomyositis, and overlay syndrome.
Antibodies against the Mi-2 protein are associated with classical dermatomyositis and are detected in 30% of patients. Antibodies against Mi-2 can also be detected in a small proportion of patients with polymyositis (<10%). The Mi-2 antigen contains two chains, and patients may have antibodies against the Mi-2α or even to the Mi-2β antigen chains. There is no known clinical difference between the antibodies directed against the two different Mi-2 chains.
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. Correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.