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Screening for antibodies against the PL-7 antigen is performed in patients with the potential for polymyositis, dermatomyositis, and overlay syndrome.

PL-7 antibodies can be detected in <5% of patients with inflammatory myositis (polymyositis / dermatomyositis). PL-7 antibodies are often associated with interstitial lung disease that may occur with or without myositis. The symptoms are similar to those observed when PL-12 antibodies are present. The PL-7 antigen corresponds to the thionyl-tRNA-synthase enzyme.

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