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Screening for antibodies againt the PL-12 antigen is performed in patients with the potential for polymyositis, dermatomyositis, and overlay syndrome.

PL-12 antibodies can be detected in <5% of patients with inflammatory myositis (polymyositis / dermatomyositis). PL-12 antibodies are often associated (90%) with interstitial pulmonary disease that may occur with or without myositis. The PL-12 antigen corresponds to the alanyl tRNA-synthase enzyme.


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