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Screening for antibodies against the SAE1 antigen is performed to investigate polymyositis, dermatomyositis, and overlay syndrome.

Antibodies against the SAE1 or SUMO-1 antigen can be detected in <10% of patients with dermatomyositis. The clinical picture includes Gottron's dots and sun rash on the eyelids. Symptoms and signs of skin often precede myositis as well as dysphagia. Interstitial lung disease may also occur.

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