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ANNA-3 Antibodies

Screening for antibodies against the ANNA-3 antigen is used in the investigation of patients with possible paraneoplastic syndrome.

ANNA-3 antigen is a rare paraneoplastic marker that has been detected in patients with small cell lung cancer and in patients with lung and esophageal adenocarcinoma. Clinical symptoms include sensory-motor neuropathy with or without ataxia, cerebral ataxia, cerebral brainstem encephalopathy with sensory disorders. Antibodies may coexist with other paraneoplastic markers such as antibodies against Ri antigens (Nova-1) and calcium channels (VGCC).

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