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Antimullerian Hormone (AMH), Serum

Antimilleric hormone (AMH), also known as milliliter inhibitory substance (MIS), is produced by testicular Sertoli cells in men and ovarian red blood cells in women, with a tribal morphological motif making it a useful marker in controlling gonads, both in men and women. Antimilleric hormone is a glycoprotein member of the TGF superfamily, the growth factor that regulates tissue growth and differentiation.

Antimilleric hormone in men

The prenatal secretion of AMH triggers Muller's regurgitation to facilitate the normal development of the male reproductive system. Antimilleric hormone in men is usually higher before puberty than in adolescence or adults. Antimilleric hormone is used in the evaluation of sex disorders and gonadal function in men.

Antimilleric hormone in women

Antimilleric hormone is generally not detectable in pre-adolescent women, but increases during reproductive age and decreases during menopause. Recent studies show that AMH levels are correlated with the status of the follicles and the ovarian deposit. Antimilleric hormone may play a role in ovulation and the onset of menopause. Antimilleric hormone is also associated with red cell tumors and may be a useful marker for monitoring these ovarian tumors.

The clinical utility of antimiller hormone measurement is:

Assessment of fertility potential in women. AMH serum levels are correlated with the number of follicles with greater specificity than inhibin B, estradiol, follicle stimulating hormone, and luteinizing hormone when measured on day 3 of the cycle. Thus, AMH may reflect the condition of the follicles better than other hormonal markers.

Measuring ovarian aging. Decreased ovarian reserve, associated with a poor response to IVF, is signaled by decreased basal levels of serum antimillatory hormone. AMH appears to be a useful indicator for predicting ovarian aging and the potential for successful IVF.

Predicting the onset of menopause. The duration of the menopausal transition can vary greatly from woman to woman, and reproductive ability can be seriously compromised before clinical diagnosis. Measurement of AMH may predict the onset of menopausal transition.

Evaluation of polycystic ovary syndrome. Serum AMH levels are elevated in patients with polycystic ovary syndrome and may be useful as an indicator for disease monitoring.

Monitoring of patients with ovarian tumors. Serum AMH concentrations are increased in some patients with ovarian granule cell tumors, which account for approximately 10% of ovarian tumors.

 

 

Important Note

Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. Correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".

Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.

At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.

 

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