The measurement of anti-ribosomal antibodies is used in laboratory testing of lupus erythematosus and in particular when findings from the central nervous system coexist.
Human ribosomes are made up of approximately equal amounts of protein and RNA. The largest subunit (60S) contains 3 acidic phosphoproteins. It is known that sera from some patients with lupus erythematosus (LE) react with ribosomal protein antigens. Anti-ribosomal antibodies (or anti-ribosomal P) are considered highly specific for lupus erythematosus and have been found in patients with central nervous system (CNS) involvement in so-called "lupus psychosis". The incidence of anti-ribosomal antibodies in patients with systemic lupus erythematosus is approximately 12%.
Since patients with systemic lupus erythematosus may exhibit CNS signs and symptoms including neuropsychiatry, the presence of anti-ribosomal antibodies is useful in the differential diagnosis of these patients. Other causes of CNS symptoms in patients with systemic lupus erythematosus include thrombosis with or without phospholipid antibodies and iatrogenic effects from corticosteroid therapy.
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. Correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
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