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Enteroviruses, Molecular Detection

Molecular testing for the presence of Enteroviruses is used for the laboratory diagnosis of infections by these viruses.

Enteroviruses are RNA viruses belonging to the family Picornaviridae. Enteroviruses were initially classified according to their serotype as Polioviruses (3 types), Echo viruses (31 types), Coxsackie A viruses (23 types) and Coxsackie B viruses (6 types). However, more recent genetic studies have shown that there is a significant overlap in the biological characteristics of the different serotypes, and the newly isolated Enteroviruses are now called consecutive numbers (eg EV68, EV69).

The most common replication site for Enteroviruses is the gastrointestinal tract where the infection is usually subclinical. However, in a proportion of cases, viruses spread to other organs, causing various manifestations, such as mild respiratory disease (eg common cold), conjunctivitis, hand, foot and mouth disease, aseptic meningitis, myocarditis and acute flaccid paralysis. Overall, Enteroviruses are the most common cause of upper respiratory disease in children and are also the most common cause of inflammatory diseases of the central nervous system (CNS), representing almost all viruses isolated from cerebrospinal fluid. Differentiation of Enteroviruses from other CNS-causing viruses and microbes is important for the timely and appropriate treatment of patients.

Detection of Enterovirus RNA by PCR is the fastest and most sensitive diagnostic method to diagnose CNS infection caused by these viruses.

 

 

Important Note

Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. Correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".

Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.

At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.

 

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