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Homer Antibodies 3

Antibody screening for the Homer 3 antigen is indicated in cases of suspected autoimmune encephalitis and autoimmune cerebral ataxia.

Homer proteins are a family of proteins found in the postsynaptic membrane. The Homer 3 protein is in the same positions as and regulates the activity of the metabotropic glutamic acid receptors of group I (mGluR1 and mGluR5).

The presence of autoantibodies against the Homer 3 antigen should be considered in the differential diagnosis of patients with subacute cerebral ataxia of unknown etiology.

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