URL path: Index page // Lipoprotein A (Lp(α)), A5673G Mutation

Lipoprotein A (Lp(α)), A5673G Mutation

Molecular screening for the A5673G mutation of the lipoprotein-α [Lp (a)] gene is performed to assess the risk of thrombosis in asymptomatic patients with a severe family history or in patients who have already experienced a thromboembolic episode.

Polymorphisms in the lipoprotein-α [Lp (a)] gene appear to predispose to coronary heart disease, vascular disease, early atherosclerosis, thrombosis, and stroke. The existence of the A5673G mutation, either in heterozygotes or in homozygotes, is associated with elevated levels of lipoprotein-α. Individuals with the above polymorphism have a 2-fold increased risk of developing cardiovascular disease but appear to benefit from aspirin administration.

Thrombophilia is an acquired or congenital disorder associated with thrombosis. The clinical appearance of an underlying thrombophilia mainly involves venous thromboembolism, which is manifested as deep vein thrombosis, pulmonary embolism, or superficial vein thrombosis. Other events associated with thrombophilia include prolonged (recurrent) miscarriages and complications of pregnancy such as severe preeclampsia, placental abruption, and fetal endometrial death. The demographic and environmental characteristics that contribute to the risk of venous thromboembolism in people predisposed to thrombophilia include: old age, gender (more commonly in men), obesity, surgery, trauma, hospitalization, etc. malignant neoplasms, prolonged immobility (such as long plane trips), use of certain medications (such as contraceptives, estrogens, tamoxifen and raloxifene) and certain drugs used to treat hypoglycemia equality.

 

 

Important Note

Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. Correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".

Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.

At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.

 

Additional information
Share it