Molecular testing for Parvovirus B19 is used for the laboratory documentation of the virus infection.
Human Parvovirus B19 (Parvovirus B19) is the causative virus of infectious erythema (also known as fifth disease) in children and can also cause aplastic seizures in patients with anemia. The virus can also cause arthropathies, embryopathies and graft rejection after kidney transplant.
Parvovirus B19 has a worldwide spread. The incidence of specific antibodies against the virus in Western developed societies is between 40-60% of the population. How the virus is transmitted is not well known. Droplet transmission and the fecal-oral route are the most suspected causes. Blood and blood products are contagious and so patients with multiple transfusions and drug addicts are groups with a high incidence of Parvovirus B19.
Parvovirus B19 multiplies in the bone marrow of erythrocyte precursor cells, which are then destroyed in the process. In patients who already suffer from anemia (sickle cell anemia, chronic hemolytic anemia), infection with the virus results in aplastic seizures, where the lack of red blood supply leads to worsening anemia.
The incubation period lasts 1-12 weeks. Without a characteristic early symptom, a rash suddenly appears on both cheeks that occupy their entire surface to the nose, forehead and mouth, which changes color and shape almost every day. Symptoms such as arthralgia (especially in women), pseudo-appendicitis, enteritis, and influenza may also occur.
Infections with Parvovirus B19 during pregnancy lead to miscarriages (infection at the beginning of pregnancy) and serious fetal damage (fetal hydrops), to infection at the end of pregnancy.
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. Correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.