Measurement of plasminogen activity is used in the evaluation of fibrinolysis and increased fibro-fibrinogen degradation products, in the diagnosis of the origin of hypo-fibrinogenemia, and in the diagnosis of ligneous (woody) conjunctivitis.
Plasminogen is a protein belonging to the β-globins and is found in the fibrin clots of blood vessels, soft tissues and all body cavities that are lined with endothelial cells. When the cellular repair mechanisms of the body are active, endothelial cellular enzymes activate the conversion of plasminogen to fibrinolytic enzyme plasmin and the fibrin clot lysis begins. Plasminogen has a biological half-life of 2 days.
There is a strong association between ligneous (woody) conjunctivitis and homozygous plasminogen deficiency.
Possible Interpretations of Pathological Values
- Increase: Stress, congenital abnormalities in the release of plasminogen inhibitors, deep vein thrombosis, infancy, infection, inflammation, malignancy, myocardial infarction, pregnancy, surgery. Medications: Contraceptives.
- Decrease: Cirrhosis, congenital abnormalities in the release of plasminogen activators, diffuse intravascular coagulation, fibrinolysis, vitreous disease, acquired hypoinogenesis, liver disease, nephrosis, surgery, thrombosis. Medications: Alteplase, L-asparaginase, streptokinase, urokinase.
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. Correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
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