Serum urea measurement is used to monitor renal function.
Urea is produced in the liver as a result of protein metabolism. Urea is transported by blood to the kidneys where it is excreted. Since urea is excreted by the bloodstream from the kidneys, measuring its concentration in the blood is a test of renal function and more specifically, glomerular function. Blood urea is usually determined in conjunction with creatinine level when assessing renal function. Both of these parameters should be evaluated before administration of any nephrotoxic medication.
Possible Interpretations of Pathological Values
- Increase: Acute glomerulonephritis, acute myocardial infarction, congestive heart failure, diabetes mellitus, diarrhea, gastrointestinal bleeding, high protein diet, nephrotoxicity, carbohydrate poisoning Medications: Angiotensin converting enzyme inhibitors, acetaminophen, acyclovir, allopurinol, amantadine, aminoglycosides, amiodarone, amphotericin B, antidepressants, antibiotics, beta-inhibitors, beta-inhibitors, beta-inhibitors, beta-blockers
- Decrease: Alcohol abuse, celiac disease, low protein diet, dialysis, hepatitis, increased antidiuretic hormone, hepatic failure, pregnancy, malnutrition, nephrosis, fluid overload. Medications: Chloramphenicol, streptomycin
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. Correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.