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YO Antibodies (PCA-1)

Screening for antibodies against the Yo antigen is used in the investigation of patients with possible paraneoplastic syndrome.

Antibodies against the Yo antigen (also called PCA-1 antibodies or Purkinje 1 cell antigen) are strongly associated with subcutaneous ataxia in ovarian or breast cancer. Neuropathy can also occur. Neurological symptoms can precede the diagnosis of cancer up to five years earlier.

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