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Leaky Gut Test

Leaky gut testing is a non-invasive test to assess the integrity and function of the intestinal mucosa. This test can diagnose the leaky gut syndrome, a pathologically elevated intestinal permeability that is often associated with inflammation of the gastrointestinal tract.

Leaky gut testing examines the ability of two small molecules, lactulose and mannitol, to pass through the intestinal epithelium. This test requires taking a solution of lactulose and mannitol and then collecting urine for six hours.

To whom Leaky Gut Test is addressed

The gastrointestinal tract epithelium has two main functions: (a) to absorb the important nutrients for the growth and function of the body and (b) to act as a selective barrier that keeps harmful substances away. When the integrity and functionality of this complex system are disturbed, it results in disturbances in intestinal permeability, which can lead to less absorption of nutrients (and toxins) or, conversely, to excessive absorption of nutrients (and toxic) substances.

Changes in intestinal permeability have been associated with pathological conditions, such as:

  • Gastrointestinal disorders
  • Food intolerance and food allergies
  • Chronic inflammation
  • Malabsorption of nutrients and nutritional deficiencies
  • Autoimmunities

See also

Zonulin, Serum

Zonulin, Stool

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