Semen neutral alpha-glucosidase measurement is used in the investigation of male infertility, especially in the investigation of patients with azoospermia and normal testosterone levels.
More information
Semen alpha-glucosidase can be divided into two fractions: neutral (associated with the epididymis) and acidic (derived from the prostate). In patients with azoospermia and normal androgen levels, the measurement of neutral alpha-glucosidase (NAG) in semen plasma is a reliable parameter for assessing epididymal function. Neutral alpha-glucosidase measurement is a more specific and sensitive epididymal test than other markers, such as glycerophosphocholine and L-carnitine.
The seminal plasma of azoospermic patients with bilateral occlusion between the epididymis and the ejaculatory duct contains very low levels of neutral alpha-glucosidase. In contrast, enzyme activity is normal when azoospermia is due to the cessation of sperm maturation or obstruction between the epididymis and the straight seminiferous tubules of the testes. Therefore, measuring seminal plasma neutral alpha-glucosidase in men with azoospermia allows the leading causes of this condition to be differentiated.
Low neutral alpha-glucosidase in patients with oligozoospermia may reflect partial epididymis obstruction associated with infections or other inflammatory conditions. Neutral alpha-glucosidase enzyme activity in patients with normal sperm concentration is related to the structural and functional integrity of the neck and tail of the spermatozoa, reflecting changes in the sperm membrane caused by epididymal secretion.
Important Note
Laboratory test results are the most critical parameter for diagnosing and monitoring all pathological conditions. Between 70 to 80% of diagnostic decisions are based on laboratory tests. Correctly interpreting laboratory results allows a doctor to distinguish "healthy" from "diseased."
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be analyzed based on each case and family history, clinical findings, and the results of other laboratory tests and information. Your physician should explain the importance of your test results.
At Diagnostiki Athinon, we answer any questions you may have about the test you perform in our laboratory and contact your doctor to ensure you receive the best possible medical care.
