Measurement of 17-ketosteroids in the urine is used to test adrenal cortex function.
More information
17-Ketosteroids (17-KS) are substances that are formed when the body metabolizes the steroid hormones produced by the adrenals, testes, and ovaries. Adrenal androgens measured as 17-ketosteroids include dehydroepiandrosterone, androstenedione, etiocholanolone, androsterone, and their metabolites. In males, about two-thirds of 17-ketosteroids are secreted by the adrenal cortex, while in females almost the entire amount of 17-ketosteroids is secreted by the adrenal cortex. Thus, for both sexes, the measurement of 17-keto steroids in the urine reflects the function of the adrenal cortex.
Interpretation of Pathological Index
- Increase: Cushing's syndrome, early puberty due to adrenal hyperplasia, normal stress (surgical procedures, burns, infections), stimulation by ACTH or gonadotropin
- Decrease: Addison's disease, ACTH deficiency, medication (corticosteroids, estrogens, oral contraceptives
Important Note
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. The correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings, and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.
