Determining specific IgE antibodies is used to diagnose allergic diseases and identify allergens responsible for allergies and anaphylactic reactions.
Determining specific IgE antibodies is also used to confirm sensitization before initiating immunotherapy and investigate allergic reactions to specific allergens, such as insect poisons and drugs.
Specific information
- Specific allergen: Tobacco Leaf Allergen
- Allergen code: O201
- Allergen group: Professional materials
More information
The clinical manifestations of immediate type hypersensitivity (allergy) are caused by the release of certain substances such as histamine, leukotrienes, and prostaglandins from immunoglobulin E (IgE) sensitized cells (mast cells and basophils) upon interaction with the allergen. A blood test for specific IgE antibodies indicates the immune response to the allergen.
The allergens selected for the test depend on the patient's age, history of exposure to specific allergens, time of year, and clinical manifestations. In people with a predisposition to allergic disease, the sequence of sensitization and clinical manifestations are usually as follows: eczema and respiratory manifestations (rhinitis and bronchospasm) in infants and children under 5 years due to food allergies (usually milk, eggs, and proteins), followed by respiratory manifestations (rhinitis and asthma) in older children and adults due to sensitivity to inhaled allergens (usually dust mites, mold, and pollen).
Specific IgE antibodies in the serum (class 2 or higher) indicate an increased likelihood of allergic disease. It identifies allergens that may be responsible for the onset of signs and symptoms of an allergy.
However, patients who do not display clinically significant sensitivity to allergens may have measurable serum IgE antibody levels. Because of this, a patient’s overall clinical picture should be considered when interpreting serum IgE antibody level results.
Important Note
Laboratory test results are crucial for diagnosing and monitoring all pathological conditions. 70% and 80% of diagnostic decisions are based on laboratory tests. Correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased."
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted based on each case and family history, clinical findings, and the results of other laboratory tests and information. Your physician should explain the importance of your test results.
At Diagnostiki Athinon, we answer any questions you may have about the test you perform in our laboratory and contact your doctor to ensure you receive the best possible medical care.
