A2-antiplasmin (or otherwise A2 plasmin inhibitor) is synthesized in the liver and has a biological half-life of approximately 3 days. Its main role is to inactivate plasmin, the major fibrinolytic enzyme responsible for remodeling the fibrin clot and binding fibrin together with Factor XIIIa, making clot lysis more difficult. The absence of A2-antiplasmin results in uncontrolled lysis of the fibrin clot by plasmin, which is associated with an increased risk of bleeding. A2-antiplasmin is measured to diagnose congenital deficiencies (rare conditions). Patients with congenital homozygous A2-antiplasmin deficiency (levels < 10%), show clinical symptoms (bleeding). Heterozygotes have 30% to 60% levels of average physiological activity and are usually asymptomatic.
Measurement of A2-antiplasmin provides a more complete assessment of disseminated intravascular coagulation, intravascular coagulation, fibrinolysis, and hyperfibrinolysis (primary fibrinolysis), when measured in combination with fibrinogen, D-dimers, and fibrinolysis products.
A2-antiplasmin is also measured to evaluate liver disease and the effectiveness of thrombolytic or antifibrinolytic therapy.
Lower than normal levels may indicate its consumption as a result of plasminogen activation and its inhibition by A2-antiplasmin. The clinical significance of high levels of A2-antiplasmin is unknown.
Important Note
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. The correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings, and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.
