A1-microglobulin measurement is used to evaluate the function of renal tubules.
A1-microglobulin is a low molecular weight protein synthesized in the liver, freely filtered from the kidneys, and reabsorbed by the cells of the proximal renal tubules where it is catabolized. Due to its significant resorption, under normal conditions, a very small amount of A1-microglobulin is eventually excreted in the urine. Therefore, an increase in the concentration of A1-microglobulin in the urine indicates anatomical damage to the proximal renal tubules and/or impaired function.
Elevated A1-microglobulin concentration in the urine may indicate renal tubular damage associated with renal tubular nephritis or heavy metal tubular toxicity or nephrotoxic drug exposure. Glomerulonephritis, as well as renal angiopathies, are often associated with damage to the renal tubules and thus may lead to increased secretion of A1-microglobulin. Elevated levels of A1-microglobulin in patients with urinary tract infections may indicate renal disease (pyelonephritis).
Important Note
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. The correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings, and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.
