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Brivaracetam, Serum

Serum brivaracetam measurement is used to monitor drug levels in the body during treatment, to monitor patient compliance with treatment, and to evaluate any drug toxicity. Brivaracetam is a medication that belongs to the antiepileptic drug class and is used to treat partial-onset seizures in patients with epilepsy. It was developed as a more potent analog of levetiracetam, another antiepileptic medication. Brivaracetam is sold under the brand name Briviact®.

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Mechanism of Action: Brivaracetam's exact mechanism of action is not fully understood, but it is believed to modulate synaptic vesicle protein 2A (SV2A) in the brain. SV2A regulates neurotransmitter release, and by binding to this protein, brivaracetam may help reduce abnormal neuronal activity associated with seizures.

Indications: Brivaracetam is approved for the treatment of partial-onset seizures in adults and children who are at least four years old.

Dosage: The dosage of brivaracetam varies depending on the age and weight of the patient. It is typically administered orally as tablets or as an oral solution.

Side Effects: Common side effects of brivaracetam may include drowsiness, dizziness, fatigue, nausea, and headache.

Precautions: Brivaracetam should be used with caution in patients with a history of psychiatric disorders, as it may cause psychiatric and behavioral reactions. Doctors must monitor patients for any signs of mood changes, aggression, or suicidal thoughts.

Pregnancy and Breastfeeding: Pregnant women and those planning to become pregnant should consult with their doctors before using brivaracetam. It may pass into breast milk, so breastfeeding mothers should discuss the possible risks and benefits.

Efficacy: Brivaracetam has demonstrated efficacy in reducing seizure frequency in clinical trials. However, its effectiveness can vary between individuals.

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