Serologic testing for Candida is used to diagnose and monitor patients with candidiasis.
Candidiasis, also known as moniliasis, is caused by the yeast Candida albicans. It affects mucous membranes, skin, and nails. This microorganism is a fungus and can normally be found in small numbers, in vaginal secretions, the intestine, and the oral cavity. Under certain circumstances, the growth of the microorganism can occur rapidly. Such cases include long-term antibiotic therapy, corticosteroid therapy, pregnancy, contraceptives, diabetes, and immunosuppressed patients. Oral candidiasis can often be the first sign of AIDS. The serological test for Candida is used in conjunction with histological tests and cultures to confirm the diagnosis and is particularly useful when other tests are unclear.
IgG antibodies are the predominant antibodies formed during secondary exposure to Candida and reflect past or continuing infection. IgG antibodies are produced when IgM antibody levels decrease after initial (primary) exposure. IgG antibodies activate the complement and assist the phagocytic system to eliminate antigens from the extravascular space. IgG antibodies represent the major class of human immunoglobulins and are evenly distributed both intravascular (in blood serum) and extravascular fluid. Specific IgG antibodies can be detected for many years after the infection is eliminated.
Possible Interpretations of Pathological Values
- Increase: Candida infection
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. The correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings, and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.