The measurement of VLDL cholesterol in serum is used to determine the risk of developing cardiovascular disease.
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Very Low-Density Lipoproteins (VLDL) transport the body's cholesterol and triglycerides in the plasma from the liver to the rest of the body's organs and are deposited in peripheral tissues. As VLDL is broken down, the Low-Density Lipoprotein (LDL) remnants remain in the bloodstream. VLDL contains the apolipoproteins Apo B-100, Apo E, and Apo C. Excessive intake of carbohydrates, saturated fatty acids, and trans fatty acids enhances the hepatic synthesis of triglycerides, which in turn increases the production of VLDL.
Possible Interpretations of Pathological Values
- Increase: Acute myocardial infarction, anorexia nervosa, coronary artery disease, Cushing's disease, diabetes mellitus, diet high in cholesterol and saturated fats, dysglobulinemia, eclampsia, liver disease, type II hyperlipoproteinemia, hyperlipidemia, hypothyroidism, Laënnec cirrhosis, multiple myeloma, nephrotic syndrome, obesity (often), porphyria, pregnancy, renal failure. High levels are associated with an increased risk of atherosclerotic coronary artery disease. Medications: Androgens, aspirin, catecholamines, diuretics, corticosteroids, oral contraceptives, phenothiazines, sulfonamides
- Decrease: Arteriosclerosis, abetalipoproteinemia, chronic obstructive pulmonary disease, hyperlipoproteinemia type I, hyperthyroidism, hypoalbuminemia, inflammatory joint disease, malabsorption, malnutrition, multiple myeloma, lung disease, Reye's syndrome, stress, Tangier disease. Medications: Aspirin, cholestyramine, clofibrate, cortisone, estrogens, neomycin, nicotinic acid, probucol, tamoxifen, thyroxine. Herbs and natural remedies: Garlic, soy, herbs containing guar gum, etc.
Important Note
Laboratory test results are the most critical parameter for diagnosing and monitoring all pathological conditions. Between 70 to 80% of diagnostic decisions are based on laboratory tests. Correctly interpreting laboratory results allows a doctor to distinguish "healthy" from "diseased."
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be analyzed based on each case and family history, clinical findings, and the results of other laboratory tests and information. Your physician should explain the importance of your test results.
At Diagnostiki Athinon, we answer any questions you may have about the test you perform in our laboratory and contact your doctor to ensure you receive the best possible medical care.
