Serum cyclosporine is used to monitor drug levels in the body during treatment, to monitor patients' compliance with treatment, and to evaluate any drug toxicity.
Cyclosporine (Sandimmun) is an immunosuppressive agent derived from the fungus Tolypocladium inflatum. Cyclosporin is used to control graft rejection, especially in organs such as the liver, heart, and kidneys. The efficacy of cyclosporin is due to the specific and reversible inhibition of immunocompetent lymphocytes in the G0 and G1 phases of their cell cycle. T-cells and especially helper T-cells are selectively inhibited, although suppressive T-cells may also be suppressed. Cyclosporin also inhibits the production and release of cytokines, including interleukin 2.
Cyclosporine has many interactions with other drugs, resulting in an increase in neuro- and nephrotoxicity when co-administered with antibiotics, antifungals, or other immunosuppressants.
Cyclosporine has a narrow therapeutic range, with frequent side effects making it necessary to monitor its blood concentration.
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. The correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings, and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.