The measurement of ethosuximide is used to monitor drug levels in the body during treatment, to monitor patient compliance, and to check for potential drug toxicity.
Ethosuximide (Ehosuximide, Zarontin) is used to treat petit mal seizures, although valproic acid is more commonly used for this condition. Ethosuximide is completely absorbed by the gastrointestinal tract, reaching its peak plasma concentration in 1 to 7 hours. About 10-20% of the drug is excreted unchanged in the urine while the rest is metabolized by the liver enzymes. The half-life of ethosuximide is 40 to 50 hours with only a small percentage circulating in the blood binding to proteins.
Ethosuximide exhibits barbiturate-like toxicity characterized by central nervous system depression and respiratory depression, nausea, and vomiting when blood levels are > 150 µg/mL.
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. The correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings, and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.