The measurement of serum flunitrazepam is used to monitor drug levels in the body during treatment, to monitor patients' compliance with treatment, and to evaluate any drug toxicity.
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Flunitrazepam (Flunitrazepam, Hipnosedeon, Ilman, Neo Nifalium, Vulbegal, Narcozep, Rohypnol, Primun, Rohipnol, Roipnol) is an intermediate-acting benzodiazepine that is used as a hypnotic, sedative, anxiolytic and muscle relaxant drug. In general, flunitrazepam as a hypnotic is intended for the short-term treatment of chronic or severe insomnia that does not respond to other hypnotics, especially in hospitalized patients.
Oral administration of flunitrazepam results in an 80% absorption rate, whilst the bioavailability of the drug as a suppository is approximately 50%. Flunitrazepam has a half-life of 18-26 hours and an active metabolite with a half-life of 36-200 hours, which means that the effects of the drug after night administration may persist into the next day. This can affect the ability of users to drive safely and increase the risk of falls. Flunitrazepam is lipophilic and metabolized in the liver through oxidative pathways. The enzyme CYP3A4 is the major enzyme for the metabolism of the drug in liver microsomes.
Overdose of flunitrazepam can lead to excessive depression, balance and speech disorders. This can develop into respiratory depression or coma and possibly death. The risk of overdose is increased if taken in combination with CNS suppressants, such as alcohol and opioids.
Important Note
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. The correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings, and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.
