HLA antigens (Human Leukocyte Antigen) are present on the surface of white blood cells as well as on the surface of all nuclear cells in other tissues. These antigens can be more readily detected on the cell surface of the lymphocytes. The presence or absence of these antigens is genetically determined. Each gene controls the presence or absence of HLA A, B, C, or D.
The HLA system is used to aid in the diagnosis of certain diseases. For example, HLA-B27 is found in 90% of patients with ankylosing spondylitis and in 80% of patients with Reiter syndrome. HLA-B27 is present in 5 to 7% of the normal population.
The HLA antigen system has been used for transplant donor-recipient compatibility, and since HLA antigens are genetically determined, they can also be used to resolve paternity issues.
What diseases are associated with the presence of HLA B27?
- Ankylosing spondylitis (Marie-Strümpell disease)
- Rheumatoid arthritis
- Congenital adrenal hyperplasia
- Goodpasture syndrome
- Narcolepsy
- Pemphigus
- Reiter syndrome
- Spinal arthritis
- Subacute thyroiditis
Important Note
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. The correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings, and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.
