Serum hydroxybutyrate dehydrogenase measurement is used in the diagnosis of myocardial infarction.
More information
Hydroxybutyrate dehydrogenase (HBDH) is an enzyme similar to lactate dehydrogenase 1 (LDH1) found in the brain, heart muscle, kidneys, and red blood cells. It is generally used to diagnose myocardial infarction, although its levels may also be elevated when there is damage to other organs. Measurement of HBDH levels is more specific and takes longer than creatine kinase (CPK), oxaloacetate transaminase (SGOT/AST), and total lactate dehydrogenase (LDH) measurement to diagnose myocardial infarction. Hydroxybutyrate dehydrogenase levels increase within 8-10 hours after the onset of infarction, peak at 48-96 hours after, and remain abnormal for 16-18 days.
Possible Interpretations of Pathological Values
- Increase: Anemia (hemolytic or megaloblastic), carbon monoxide poisoning, hepatocellular damage, leukemia, lymphoma, malignant melanoma, muscular dystrophy, myocardial infarction, nephrotic syndrome, orthopedic surgeries.
Important Note
Laboratory test results are the most critical parameter for diagnosing and monitoring all pathological conditions. Between 70 to 80% of diagnostic decisions are based on laboratory tests. Correctly interpreting laboratory results allows a doctor to distinguish "healthy" from "diseased."
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be analyzed based on each case and family history, clinical findings, and the results of other laboratory tests and information. Your physician should explain the importance of your test results.
At Diagnostiki Athinon, we answer any questions you may have about the test you perform in our laboratory and contact your doctor to ensure you receive the best possible medical care.
