The measurement of hydroxyproline in urine is used for the laboratory diagnosis and monitoring of Paget's disease of bone, for investigating inflammatory or neoplastic bone involvement, as an indicator of activity in acromegaly, for monitoring growth hormone therapy, and as a complementary test for the diagnosis of Marfan syndrome.
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Hydroxyproline is an amino acid found in collagen. Urine hydroxyproline excretion is a helpful indicator of collagen metabolism (degradation). It reflects the rate of bone breakdown and is a good test for monitoring the status of Paget's disease.
Possible Interpretations of Pathological Values
- Increase: Acromegaly, Albright syndrome, bone cancer, bone metastases, osteopenia, burns, congenital hypophosphatemia, diabetes mellitus, gastroenteritis, growth, fracture healing, hyperparathyroidism, hyperpituitarism, hyperprolinemia type II, hyperthyroidism, Marfan syndrome, multiple myeloma, osteomalacia, osteomyelitis, Paget's disease of bone, psoriasis, rickets. Medications: Growth hormone, parathyroid hormone, phenobarbital, sulfonylureas.
- Decrease: Hypoparathyroidism, hypopituitarism, hypothyroidism, malnutrition, muscular dystrophy. Medications: Acetylsalicylic acid, antineoplastic agents, ascorbic acid, calcitonin, calcium gluconate, corticosteroids, bisphosphonates, ergocalciferol, estradiol, estriol, glucocorticoids, mithramycin, propranolol
Important Note
Laboratory test results are the most critical parameter for diagnosing and monitoring all pathological conditions. Between 70 to 80% of diagnostic decisions are based on laboratory tests. Correctly interpreting laboratory results allows a doctor to distinguish "healthy" from "diseased."
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be analyzed based on each case and family history, clinical findings, and the results of other laboratory tests and information. Your physician should explain the importance of your test results.
At Diagnostiki Athinon, we answer any questions you may have about the test you perform in our laboratory and contact your doctor to ensure you receive the best possible medical care.
