Measurement of immunoglobulin G assesses humoral immunity and is also used in monitoring IgG myeloma treatment.
Immunoglobulin G (IgG) consists of four subgroups, IgG1, IgG2, IgG3, and IgG4, and accounts for 75% of all immunoglobulins in the bloodstream. IgG antibodies have activity against viruses, certain bacteria, and toxins. They can cross the placenta provide immunity to the developing embryo and also act as a complement system activator. IgG antibodies increase in response to infections and remain elevated, even if the infection is chronic.
Immunoglobulin G is also important in autoimmune diseases because many of the autoantibodies belong to this class (class of antibodies).
What Do Pathological Values Mean?
- Increase: Infections (chronic or recurrent), liver disease (chronic), malignancies (lymphomas), multiple myeloma, pulmonary tuberculosis, rheumatoid arthritis, sarcoidosis, systemic lupus erythematosus, toxoplasmosis, Waldenstrom disease.
- Decrease: Acquired immunodeficiency syndrome, aplastic anemia, humoral immune deficiency, Wiscott-Aldrich syndrome.
Important Note
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. The correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings, and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.
