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Lamotrigine, Serum

Serum lamotrigine is used to monitor drug levels in the body during treatment, to monitor patient compliance with treatment, and to evaluate any drug toxicity.

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Lamotrigine (Lamictal) is used to treat bipolar disorders as well as various epileptic disorders, including Lennox-Gastaut syndrome, primary generalized tonic-clonic seizures, and focal seizures. Lamotrigine has also been used in the treatment of migraine, trigeminal neuralgia, and other treatment-resistant depression. Lamotrigine inhibits the release of glutamic acid (a stimulatory amino acid) and sodium channels to stabilize the neuronal membranes. It also weakly inhibits 5-HT3 (serotonin) receptors.

The bioavailability of orally administered lamotrigine is very high (approximately 98%). The drug is metabolized by conjugation with glucuronic acid to inactive metabolites. Its half-life is 25-33 hours in adults but is reduced by concomitant use of phenytoin or carbamazepine (13-14 hours) and increased by co-administration of valproic acid (59-70 hours) and in patients with renal or hepatic impairment or insufficiency.

Common side effects of lamotrigine include dizziness, ataxia, blurred or double vision, nausea, or vomiting.



Important Note

Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. The correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".

Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings, and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.

At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.

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