Determination of M2 anti-mitochondrial antibodies is used to confirm primary biliary cirrhosis.
Anti-mitochondrial antibodies (AMA) are detectable in 90% of patients with primary biliary cirrhosis (PBC) and to a lesser extent in patients with other autoimmune diseases. The mitochondrial antigens recognized by the patients' anti-mitochondrial antibodies have been characterized and classified numerically from M1 to M9. The M2 antigen is composed of several enzymatic proteins found in the inner mitochondrial membranes such as pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase.
The presence of M2 anti-mitochondrial antibodies is very specific and substantially diagnostic for primary biliary cirrhosis while false-negative results are rare.
Important Note
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. The correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings, and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.
