Neopterin is a naturally occurring molecule and a valuable biomarker in clinical and immunological research. It is primarily produced by immune system cells, such as macrophages, in response to various immune challenges, particularly inflammation and oxidative stress.
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Neopterin is produced as part of the body's defense mechanism when the immune system is activated in response to infections, autoimmune diseases, or other inflammatory conditions. It serves as a sensitive and specific marker of cellular immune activation. Elevated neopterin levels in body fluids, such as urine or blood, indicate an ongoing immune response.
Neopterin measurement is widely used in clinical settings to diagnose and monitor various diseases and conditions. Some of its applications include:
- Infectious Diseases: Elevated neopterin levels are often observed in infections, making it a helpful marker for diagnosing and monitoring viral and bacterial diseases, including HIV/AIDS.
- Autoimmune Disorders: Conditions like rheumatoid arthritis, systemic lupus erythematosus (SLE), and multiple sclerosis can increase neopterin levels due to immune system activation.
- Cancer: Neopterin has been explored as a potential marker for certain types of cancer, as increased levels may be associated with malignancies.
- Transplantation: Neopterin can be used to monitor organ transplant recipients. Changes in neopterin levels can indicate graft rejection.
- Cardiovascular Diseases: Elevated neopterin levels have been linked to atherosclerosis and coronary artery disease.
- Neurological Disorders: In conditions like Parkinson's disease and Alzheimer's disease, neopterin levels may be elevated, reflecting neuroinflammation.
Neopterin levels should be interpreted in the context of the specific clinical situation and in conjunction with other clinical and laboratory findings. Elevated neopterin levels suggest ongoing immune activation or inflammation, possibly due to underlying causes.
Increase: Autoimmune diseases (e.g., rheumatoid arthritis), bacterial diseases (especially tuberculosis and leprosy), acquired immunodeficiency syndrome (AIDS), viral infections, generalized lymphadenopathy syndrome (LAS), graft-versus-host reaction, protozoan infections (malaria), pregnancy (from the 20th week), transplant rejection, various malignant diseases (e.g. hematopoietic diseases, germ cell tumors, neurogenic tumors), less frequently in tumors of the urogenital tract, pancreas, gall bladder, gastrointestinal tumors, breast and bronchial carcinoma.
