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Osmotic Fragility, Erythrocytes

Measurement of red blood cell osmotic resistance is used for the control of hereditary spherocytes as well as for the confirmation and control of mild spherocytes.

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Spherocytes (i.e. globular-shaped red blood cells) are osmotically fragile cells and rupture more readily in a hypotonic solution than normal red blood cells. As they have a smaller surface-to-volume ratio, they are easier to dissolve than normal disc-shaped red blood cells. Cells that have a higher surface-to-volume ratio, such as target cells and pale red blood cells, are more resistant to lysis.

Patients with G-6-PD deficiency or pyruvate kinase or other red blood cell disorders may test positive.




Important Note

Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. Correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".

Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.

At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.

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