Measurement of plasminogen activity is used in the evaluation of fibrinolysis and increased fibrin-fibrinogen degradation products, in the diagnosis of the origin of hypofibrinogenemia, as well as for the diagnosis of ligneous (woody) conjunctivitis.
More Information
Plasminogen is a protein belonging to the beta globins family. It is found in fibrin clots in blood vessels, soft tissues, and all body cavities lined with endothelial cells. When the body's cellular repair mechanisms are activated, endothelial cell enzymes convert plasminogen to the fibrinolytic enzyme plasmin, and fibrin clot lysis begins. Plasminogen has a biological half-life of two days.
There is a strong association between ligneous (woody) conjunctivitis and homozygous plasminogen deficiency.
Possible Interpretations of Pathological Values
- Increase: Stress, congenital abnormalities in the release of plasminogen inhibitors, deep vein thrombosis, infancy, infection, inflammation, malignancy, myocardial infarction, pregnancy, surgery. Medications: Contraceptives.
- Decrease: Cirrhosis, congenital abnormalities in the release of plasminogen activators, disseminated intravascular coagulation, fibrinolysis, hyaline membrane disease, acquired hypofibrinogenemia, liver disease, nephrosis, surgery, thrombosis. Medications: Alteplase, L-asparaginase, streptokinase, urokinase.
Important Note
Laboratory test results are the most critical parameter for diagnosing and monitoring all pathological conditions. Between 70 to 80% of diagnostic decisions are based on laboratory tests. Correctly interpreting laboratory results allows a doctor to distinguish "healthy" from "diseased."
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be analyzed based on each case and family history, clinical findings, and the results of other laboratory tests and information. Your physician should explain the importance of your test results.
At Diagnostiki Athinon, we answer any questions you may have about the test you perform in our laboratory and contact your doctor to ensure you receive the best possible medical care.
