Serum primidone measurement is used to monitor drug levels in the body during treatment, to monitor patients' compliance with treatment, and to evaluate any drug toxicity.
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Primidone (Mysoline) is an anticonvulsant used in the treatment of temporal lobe epilepsy and grand mal epileptic seizures that are resistant to other anticonvulsant drugs. When metabolized by the liver, primidone is broken down into phenobarbital and phenylethylmalonamide. These two metabolites exert synergistic action. The kidneys excrete the metabolites of primidone. The half-life of primidone is 4-12 hours in adults and 4-6 hours in children. Steady-state levels are reached after 16-60 hours in adults and 20-30 hours in children, while peak plasma drug concentration is reached 2-4 hours after administration.
At toxic concentrations, primidone can cause a reduced level of consciousness, ataxia, and anemia, while side effects include sedation, dizziness, nausea, vomiting, nystagmus, and loss of libido.
An increase in the concentration of primidone is caused by carbamazepine, isoniazid, monoamine oxidase (ΜΟΑ) inhibitors, phenobarbital, and sodium valproate. A decrease in the concentration of primidone is caused by sub-maximal treatment, acetazolamide, and methoxuximide.
Important Note
Laboratory test results are the most critical parameter for diagnosing and monitoring all pathological conditions. Between 70 to 80% of diagnostic decisions are based on laboratory tests. Correctly interpreting laboratory results allows a doctor to distinguish "healthy" from "diseased."
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be analyzed based on each case and family history, clinical findings, and the results of other laboratory tests and information. Your physician should explain the importance of your test results.
At Diagnostiki Athinon, we answer any questions you may have about the test you perform in our laboratory and contact your doctor to ensure you receive the best possible medical care.
