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Propoxyphene (PPX), Urine

This test detects the presence of propoxyphene (PPX), a synthetic opioid analgesic, in urine.

Propoxyphene, also known by its brand name Darvocet, is a medication that was previously used to relieve mild to moderate pain. It is an opioid analgesic, and it works by affecting the central nervous system to reduce pain perception. Propoxyphene was often used in combination with acetaminophen (paracetamol).

The decision to withdraw propoxyphene was based on concerns about its potential to cause serious and sometimes fatal heart rhythm abnormalities, specifically prolongation of the QT interval on the electrocardiogram (ECG). These heart rhythm abnormalities could potentially lead to a condition called Torsades de Pointes, a life-threatening arrhythmia.

Propoxyphene, like other opioids, can cause side effects such as dizziness, drowsiness, nausea, and constipation.

The time frame during which propoxyphene can be detected in urine depends on factors like the specific drug test being used, the dose of the medication, and an individual's metabolism. Generally, propoxyphene may be detectable in urine for a few days to a week after last use.

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