Rose Bengal agglutination test is used as an initial screening test for patients with suspected brucellosis.
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Various antibody classes are produced during a human infection by any pathogenic microorganism. Among these antibodies are agglutinins. When combined with the homologous antigen (agglutinogen) under controlled conditions, an agglutinin can cause agglutination.
Rose Bengal agglutination test uses Brucella microbial antigen for early detection of adhesins against species of Brucella (Brucella abortus, Brucella melitensis, and Brucella suis). This test is an initial screening test only for detecting agglutinins against Brucella. If the result is positive, it should be confirmed by other more specific serological tests for brucellosis.
Detectable agglutinins do not always indicate bacterial infection. In some cases, nonspecific agglutinins may react with Brucella antigens. For example, sera from certain classes of drug addicts have been reported to contain significant amounts of agglutinins. In some cases, cross-reactions may occur, such as tularemia. In addition, vaccinations can produce agglutinins capable of reacting with soluble antigens.
Important Note
Laboratory test results are the most critical parameter for diagnosing and monitoring all pathological conditions. Between 70 to 80% of diagnostic decisions are based on laboratory tests. Correctly interpreting laboratory results allows a doctor to distinguish "healthy" from "diseased."
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be analyzed based on each case and family history, clinical findings, and the results of other laboratory tests and information. Your physician should explain the importance of your test results.
At Diagnostiki Athinon, we answer any questions you may have about the test you perform in our laboratory and contact your doctor to ensure you receive the best possible medical care.
