Amyloid A (SAA) measurement is used in the diagnosis and evaluation of various inflammatory conditions, as an acute-phase protein.
Amyloid A is not a substance, but it is actually a family of proteins associated with high-density cholesterol (HDL). So far, 3 different genes and proteins that constitute amyloid A have been found.
Amyloid A is secreted during the acute phase of inflammation. These proteins have various roles, including the transfer of cholesterol to the liver for biliary secretion, the guidance of immune cells to sites of inflammation, and the induction of extracellular-degrading enzymes. Amyloid A proteins have been implicated in various chronic inflammatory diseases, such as amyloidosis, atherosclerosis, and rheumatoid arthritis.
Serum amyloid A is an acute inflammation marker that responds quickly. Like CRP, levels of amyloid A increase within a few hours after inflammatory stimulation and the magnitude of its increase may be greater than that of CRP. Relatively small inflammatory stimuli may also lead to an increase in SAA. SAA levels are better associated with rheumatoid arthritis activity at the onset of the disease than ESR and CRP.
Although amyloid A is largely produced by hepatocytes, recent studies show that it is also produced by adipocytes and its concentration in serum is linked to body mass index (BMI).
Important Note
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. The correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings, and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.
