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Squamous Cell Carcinoma Antigen (SCC), Serum

Squamous cell carcinoma (SCC) antigen is a glycoprotein contained in a neutral form within normal tissue epithelial cells but released in acid form when squamous cell carcinomas or benign lesions are present.

SCC levels are associated with the progression of the disease in some squamous cell carcinomas and their response to treatment, as well as a prognostic indicator for these diseases. After removing the pathological lesions, SCC levels reach normal within about 4 days.

What Do Pathological Values Mean?
  • Increase: squamous cell carcinomas (anal, cervical, esophagus, lung, head, neck, penis, skin, uterus). Higher levels of SCC antigen after treatment indicate progression of carcinoma. They may also be elevated in up to 3% of healthy individuals as well as in acute respiratory distress syndrome, benign skin diseases (eczema, pemphigus, psoriasis), in endometriosis, in liver disease (cirrhosis, hepatitis), in inflammatory pelvic diseases, pleuritis, pneumonia, kidney failure, sarcoidosis, and tuberculosis.
  • Decrease: After radiation of lesions in patients with previous high SCC values.



Important Note

Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. The correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".

Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings, and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.

At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.

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