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8-Iso Prostaglandin F2a (8-Iso F2a)

8-iso-prostaglandin F2α is an isoprostane formed as a result of lipid peroxidation due to oxidative stress. Elevated levels of this molecule can indicate increased oxidative stress and potential tissue damage. It is used as a biomarker to study the role of oxidative stress in various diseases and conditions.

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This prostaglandin (8-iso-PG F2α), derived by the non-enzymatic free radical catalyzed peroxidation of arachidonic acid, an essential fatty acid present in various food sources, functions as an inflammatory mediator. It participates in multiple biological processes such as vasodilation, pain perception, and immune regulation.

8-epi-prostaglandin F2α, also known as 8-iso-prostaglandin F2α or 8-iso-PG F2α, is a molecule derived from the prostaglandin family, specifically from the F2 series of prostaglandins. It is a biologically active compound, but it is not a typical prostaglandin that is produced in the body under normal circumstances. Instead, 8-epi-prostaglandin F2α is an isoprostane, which is a type of molecule formed by the peroxidation of lipids, particularly arachidonic acid, in response to oxidative stress or inflammation. It is produced when oxidative stress leads to the peroxidation of lipids in cell membranes, resulting in the formation of this isoprostane.

8-epi-prostaglandin F2α is considered a marker of oxidative stress in the body. It is associated with various pathological conditions, including inflammation, cardiovascular diseases, and oxidative damage to cells.

Clinical Significance: Elevated levels of 8-epi-prostaglandin F2α in biological samples, such as blood or urine, can indicate increased oxidative stress and potential damage to tissues. Therefore, it is often used as a biomarker in clinical and research settings to assess oxidative stress and its role in various diseases.

Oxidative Stress: Oxidative stress is an imbalance between the production of reactive oxygen species (ROS) and the body's ability to neutralize them with antioxidants. Excessive oxidative stress is associated with numerous health conditions, including cardiovascular disease, neurodegenerative disorders, and cancer.

Antioxidant Defense: The body has natural defense mechanisms, including antioxidants, to counteract the harmful effects of oxidative stress. Maintaining a balance between pro-oxidants and antioxidants is essential for overall health.

Lipid peroxidation is a well-defined mechanism of cell damage in animals and plants. Lipid peroxides are unstable markers of cellular oxidative stress and are rapidly degraded to form more complex and reactive molecules such as isoprostanes. Isoprostanes are a type of eicosanoid produced non-enzymatically through the peroxidation of tissue phospholipids and lipoproteins by oxygen-free radicals. Isoprostanes are prostaglandin-like compounds that occur normally in plasma and urine but are increased during oxidative stress in tissues, plasma, and urine.

Measurement of 8-Iso Prostaglandin F2a (also known as 8-epi-PGF2a, 8-isoprostane, and 15-isoprostane F2t), has been shown to be useful in assessing oxidative stress in vivo. It is produced from membrane phospholipids by the non-enzymatic and enzymatic (cyclooxygenase) peroxidation of arachidonic acid. 8-Iso Prostaglandin F2a is a potent vasoconstrictor, a mutagen for 3T3 cells as well as vascular smooth muscle cells, as well as a potential pathophysiological mediator that can alter cell membrane integrity. It has been implicated in atherogenesis and elevated levels are associated with hepatorenal syndrome, rheumatoid arthritis, and carcinogenesis as well as atherosclerosis. 8-Iso Prostaglandin F2a circulates in the plasma and is excreted in the urine. 8-Iso Prostaglandin F2a circulates as an esterified LDL phospholipid and as a free acid.

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