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Proline is the precursor of hydroxyproline, which is manufactured into collagen, tendons, ligaments, and heart muscle by the body. Proline is involved in wound healing, plays important roles in molecular recognition, and is an important component in certain medical wound dressings that use collagen to stimulate wound healing. Proline helps in the healing of cartilage and the strengthening of joints, tendons, and heart muscles, and it works with vitamin C to promote healthy connective tissues. Measurement of proline is included in the Amino Acids, Plasma and Amino Acids, Urine tests along with 23 other amino acids.

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Proline (Pro/P) is a non-essential amino acid, which means that the human body can synthesize it on its own from other amino acids. It is one of the twenty standard amino acids that are used by cells to build proteins.

Proline has a unique structure that sets it apart from other amino acids. It has a cyclic structure in its side chain, which makes it more rigid than other amino acids that have a more flexible structure. This rigidity allows proline to play important roles in protein structure, stability, and function.

Proline has several important biological roles. It is a key component of collagen, the most abundant protein in the human body, and is important for maintaining the structure and function of many tissues, including skin, bone, cartilage, and tendons. Proline is also involved in energy metabolism, and neurotransmitter synthesis, and has antioxidant activity.

Protein structure: Proline is unique among the 20 standard amino acids because it has a cyclic structure that allows it to form kinks in the polypeptide chain. These kinks can have important effects on protein structure, stability, and function.

Collagen synthesis: Proline is a key component of collagen, the most abundant protein in the human body. Collagen provides strength and structure to many tissues, including skin, bone, cartilage, and tendons.

Antioxidant activity: Proline has been shown to have antioxidant activity, which means it can help protect cells from damage caused by reactive oxygen species.

Energy metabolism: Proline can be metabolized to generate energy through a process called the proline cycle. This cycle helps maintain cellular energy balance and can be particularly important during times of stress or low energy availability.

Neurotransmitter synthesis: Proline is a precursor to the neurotransmitter gamma-aminobutyric acid (GABA), which has important roles in the central nervous system, including regulating anxiety and mood.

Proline is an amino acid that is found in many types of food, particularly in protein-rich foods such as meat, fish, eggs, and dairy products. Plant-based sources of proline include soybeans, legumes, nuts, and grains.

The amount of proline in food can vary depending on several factors, including the type of food, how it is prepared, and the quality of the protein. For example, animal-based proteins tend to have higher amounts of proline than plant-based proteins. Cooking methods such as boiling, stewing, and braising can also affect the proline content of foods. Because proline is present in many common dietary protein sources, deficiency is rare in healthy individuals who consume a balanced diet.

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