Bisphenol A and Food Intolerance

Exposure of the fetus to chemicals is associated with food intolerance in adult life. More than 20% of the world’s population suffers from food allergies or intolerances. Current evidence suggests that these food adverse reactions may be associated with environmental factors. French researchers have shown that perinatal exposure to low doses of bisphenol A (BPA) may increase the risk of developing food intolerance in adulthood. Bisphenol A (BPA) has been widely used in the production of plastic products and it is generally considered potentially responsible for endocrine disorders. Using laboratory animals, the research team observed that perinatal exposure to low doses of bisphenol A caused inflammation of the colon accompanied by neutrophil infiltration, increased interferon-γ production, and decreased TGF-β production in relation to oral tolerance and immunization to dietary antigens. The researchers of the study conclude that "the newborn's immune system is sensitive to low doses of bisphenol A, which causes food intolerance later in life."

Food intolerance at adulthood after perinatal exposure to the endocrine disruptor bisphenol A. Menard S, Guzylack-Piriou L, Leveque M, Braniste V, Lencina C, Naturel M, Moussa L, Sekkal S, Harkat C, Gaultier E, Theodorou V, Houdeau E. FASEB J. 2014 Aug 1.