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Mononucleosis Test, Serum

The mono-test is performed to rapidly diagnose infectious mononucleosis.

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Infectious mononucleosis is a viral disease that affects the reticuloendothelial system, is generally confined to children and young adults and is usually caused by the Epstein-Barr virus (EBV). The disease is characterized by fever, sore throat, lymphadenopathy, headache and fatigue and based on symptoms only, can be easily confused with other diseases. In the laboratory, infectious mononucleosis is also characterized by the presence of heterophilic antibodies.

The mono-test (mononuclear test) is a test that quickly detects heterophilic antibodies (adhesins). The positive result in the mono-test with concomitant clinical and / or hematologic findings confirms the diagnosis of infectious mononucleosis. Approximately 10% of patients with infectious mononucleosis have negative heterophilic antibodies. In these cases, specific antibodies against Epstein-Barr specific viral antigens may be present.

Heterophilic antibodies can appear in the serum around 6-10 days after contact. The presence of the antibodies can persist for up to 1 year and peak between 4 and 8 weeks after the onset of infection.

Possible Interpretations of Pathological Values
  • Increase: Adenovirus, Burkitt's lymphoma, cytomegalovirus, Epstein-Barr virus, herpes simplex virus, HIV virus, Hodgkin's disease, infectious mononucleosis, Izumi fever, leukemia, malaria, pancreatic cancer, systemic lupus erythematosus, viral or infectious hepatitis
Important Note

Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. Correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".

Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.

At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.

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