Measurement of serum transferrin saturation is used to check the state of iron in the body, whether overload or deficiency.
More information
Transferrin, or otherwise, siderophilin, belongs to the beta globulins and is a glycoprotein with a relatively short (about seven days) half-life. It is formed in the liver and transports iron from the intestinal mucosa to iron storage sites and hemoglobin synthesis sites (bone, muscle, erythrocytes, lymphocytes). Transferrin allows the transfer of iron by binding to the transferrin receptors.
Transferrin can bind more than its weight to iron (1 g can carry 1.43 g of iron). Iron saturation (transferrin saturation) is between 20 and 45%. Due to the short half-life, its values decrease more rapidly in malnutrition than albumin.
Transferrin saturation is calculated based on serum iron concentration and total iron binding capacity (TIBC). In cases of iron deficiency, the degree of transferrin saturation appears to be an extremely sensitive indicator of functional iron depletion. Transferrin saturation indicates the homozygous genotype better than ferritin when testing for hereditary hemochromatosis. Treatment of erythropoietin anemia in patients with renal impairment is effective only when sufficient iron stores are available, and the best therapy monitoring is performed by determining transferrin saturation. Determination of transferrin saturation in combination with ferritin measurement gives vital information on iron overload in patients with chronic liver disease.
Possible Interpretations of Pathological Values
- Increase: Hemochromatosis, hemodialysis, thalassemia
- Decrease: Iron anemia, neoplasms, rheumatoid arthritis, uremia
Important Note
Laboratory test results are the most critical parameter for diagnosing and monitoring all pathological conditions. Between 70 and 80% of diagnostic decisions are based on laboratory tests. Correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased."
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be analyzed based on each case and family history, clinical findings, and other laboratory tests and information. Your physician should explain the importance of your test results.
At Diagnostiki Athinon, we answer any questions you may have about the test you perform in our laboratory and contact your doctor to ensure you receive the best possible medical care.
