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Ureaplasma sp., Molecular Detection

Molecular testing for Ureaplasma sp. is a fast, specific, and sensitive way of detecting this microorganism from various biological materials.

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Ureaplasma, like mycoplasmas, belongs to the order Mollicutes. Ureaplasma urealyticum has recently been divided into two species, Ureaplasma parvum and Ureaplasma urealyticum. Ureaplasma urealyticum belongs to the common pathogens that cause infections of the genitourinary system and can be found in about 60% of sexually active people. Although of low pathogenicity, Ureaplasma urealyticum is believed to be associated with several human diseases.

In men, Ureaplasma can cause nonspecific urethritis, orchitis, and prostatitis. Ureaplasma urealyticum infection can lead to a decrease in zinc (Zn) and selenium (Se) in the sperm and, consequently, a decrease in its quality. In women, it can cause cervicitis, endometritis, salpingitis, non-specific urethritis, chorioamnionitis, stillbirth, premature birth, and in the perinatal period, pneumonia, bronchopneumonia, and meningitis. Also, it can cause narrowing of the fallopian tubes and can lead to infertility in severe cases. However, given the relatively low pathogenicity of the organism, its role in some of these diseases remains controversial. Ureaplasma is one of the causes of aseptic pyuria.

All Mycoplasmas lack the peptidoglycan wall and are, therefore, resistant to all cell wall antibiotics such as beta-lactams, fosfomycin, and glycopeptide antibiotics. They are also resistant to rifampicin, polymyxins, nalidixic acid, sulfonamides, and trimethoprim.

Ureaplasma species are generally sensitive to tetracyclines, but resistance has recently been reported. Ureaplasma species are susceptible to macrolides and related antibiotics, except for lincosamides. Ureaplasmas are intrinsically sensitive to fluoroquinolones. Newer fluoroquinolones, such as levofloxacin and moxifloxacin, are more active in vitro against mycoplasmas than older ones, such as ofloxacin and ciprofloxacin.



Important Note

Laboratory test results are the most important parameter for diagnosing and monitoring all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. The correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".

Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings, and the results of other laboratory tests and information. Your physician should explain the importance of your test results.

At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.

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