Measurement of sperm acrosin is used in the investigation of male infertility, especially when the basic sperm quality factors, sperm motility, and sperm concentration are normal. In addition, according to several studies, the measurement of acrosin is important for assessing the sperm potential for fertilization and the successful outcome of in vitro fertilization (IVF).
Acrosin is an enzyme (a serine protease) found in the inner membrane of the acrosome and participates in several important reproductive processes including, but not limited to:
- Oocyte–spermatozoon interaction
- Spermatozoon binding at the zona pellucida of the oocyte
- Sperm penetration into the zona pellucida of the oocyte
There is now plenty of evidence demonstrating the importance of acrosin in the fertilization process. Infertility is generally related to lower levels of acrosin while acrosomes are absent in sterile men. Acrosin and/or proacrosin activator inhibitors completely reduce or obstruct the entry of spermatozoa through the zona pellucida but also the entry of spermatozoa into hamster oocytes without a zona pellucida.
Since acrosine activity is usually low in patients with low concentration or low sperm motility, testing is not necessary for these patients. In couples with unexplained infertility (with normal female tests and normal sperm basic parameters), finding normal acrosine values can rule out serious pathological conditions of the spermatozoa acrosome, thus providing important information on the prognosis of infertility.
Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. 70%-80% of diagnostic decisions are based on laboratory tests. Correct interpretation of laboratory results allows a doctor to distinguish "healthy" from "diseased".
Laboratory test results should not be interpreted from the numerical result of a single analysis. Test results should be interpreted in relation to each individual case and family history, clinical findings and the results of other laboratory tests and information. Your personal physician should explain the importance of your test results.
At Diagnostiki Athinon we answer any questions you may have about the test you perform in our laboratory and we contact your doctor to get the best possible medical care.